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Open Access Research

Correlation of proteome-wide changes with social immunity behaviors provides insight into resistance to the parasitic mite, Varroa destructor, in the honey bee (Apis mellifera)

Robert Parker1, M Marta Guarna1, Andony P Melathopoulos2, Kyung-Mee Moon1, Rick White3, Elizabeth Huxter4, Stephen F Pernal2 and Leonard J Foster1*

Author Affiliations

1 University of British Columbia, Centre for High-Throughput Biology and Department of Biochemistry & Molecular Biology, 2125 East Mall, Vancouver, BC, V6T 14, Canada

2 Agriculture & Agri-Food Canada, Beaverlodge Research Farm, PO Box 29, Beaverlodge, AB, T0H 0C0, Canada

3 University of British Columbia, Department of Statistics, 2207 Main Mall, Vancouver, BC, V6T 1Z4, Canada

4 Kettle Valley Queens, 4880 Well Rd., Grand Forks, BC, V0H 1H5, Canada

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Genome Biology 2012, 13:R81  doi:10.1186/gb-2012-13-9-r81

Published: 28 September 2012

Additional files

Additional file 1:

Spreadsheet of five pages for larval dataset. Page 1, P values and protein annotation. For all proteins identified and quantitated the resultant P value from the correlation analysis with each trait and refseq annotation. Page 2, T statistic for each correlation provides a standardized value for the rate of change for each protein against per unit of each trait measured. Page 3, EGAN mapping, honey bee protein GI mapped to NCBI fly gene id. Page 4, P values for biological process gene enrichment for protein groups created by trait correlation and direction of correlation. Page 5, P values for global biological process gene enrichments.

Format: XLSX Size: 465KB Download file

Open Data

Additional file 2:

Spreadsheet of five pages for antenna dataset. Page 1, P values and protein annotation. For each protein identified the resultant P value from the correlation analysis with each trait and refseq annotation is provided. Page 2, T statistic for each correlation provides a standardized value for the rate of change for each protein against per unit of each trait measured. Page 3, EGAN mapping, honey bee protein GI mapped to NCBI fly gene id. Page 4, P values for biological process gene enrichment for protein groups created by trait correlation and direction of correlation. Page 5, P values for global biological process gene enrichments.

Format: XLSX Size: 453KB Download file

Open Data

Additional file 3:

Spreadsheet of five pages for processed antenna LC-MS data. Page 1 gives the experimental design designating used to generate LC-MS datasets. Each block is shown with colony numbers and the output file name generated for each block. Pages 2 to 4 are examples of the output from LC-MS and protein identification and quantitification result for each peptide used to generate proteins ratios. Page 5 is the result of rolling all peptide identification up into unique proteins using parsimony rules.

Format: XLSX Size: 10.3MB Download file

Open Data

Additional file 4:

Spreadsheet of five pages for processed larval LC-MS data. Page 1 gives the experimental design designating used to generate LC-MS datasets. Each block is shown with colony numbers and the output file name generated for each block. Pages 2 to 4 are examples of the output from LC-MS and protein identification and quantitification result for each peptide used to generate proteins ratios. Page 5 is the result of rolling all peptide identification up into unique proteins using parsimony rules.

Format: XLSX Size: 2.4MB Download file

Open Data