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Acting on impulse: dissecting the dynamics of the NFAT transcriptional response

Alon Kalo and Yaron Shav-Tal*

Author Affiliations

The Mina & Everard Goodman Faculty of Life Sciences & Institute of Nanotechnology, Bar-Ilan University, Ramat Gan, 52900, Israel

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Genome Biology 2013, 14:102 doi:10.1186/gb-2013-14-1-102

Published: 24 January 2013

Abstract

Examining NFAT transcription factor dynamics in single cells during signal propagation from cell membrane to the nucleus reveals unique modes of operation for protein isoforms.

Keywords:
Transcription factors; nuclear dynamics; signaling; NFAT; p53; NF-κB