Table 1

Candidate AIDS restriction genes

Year

Gene symbol

Allele

Mode

Effect

Citation(s)


1996

CCR5

Δ32

Recessive

Prevents infection

[12-14]

1996

CCR5

Δ32

Dominant

Delays AIDS

[12]

1997

CCR2

64I

Dominant

Delays AIDS

[80]

1998

CCR5P

P1

Recessive

Accelerates AIDS

[81]

1998

SDF1

3'A

Recessive

Delays AIDS

[82]

1999

CCR5

Δ32

Dominant

Prevents lymphoma

[15]

1999

HLA

A,B,C,'Homozy'

Co-dominant

Accelerates AIDS

[83]

2000

IL10

5'A

Dominant

Limits infection

[84]

IL10

5'A

Dominant

Accelerates AIDS

[84]

2001

HLA

B*35Px

Co-dominant

Accelerates AIDS

[85]

2002

RANTES

-403A

Dominant

Accelerates AIDS

[86]

In1.1C

Co-dominant

Accelerates AIDS

[86]

2002

KIR

3DS1

Epistatic

Delays AIDS

[28,29]

(Bw4-801)

2003

EOTAXIN-MCP1

Hap7

Dominant

Enhances infection

[87]

2003

HLA

B*57

Co-dominant

Delays AIDS

[88]

2003

IFNG

179T

Dominant

Accelerates AIDS

[89]

2003

CXCR6

E3K

Dominant

Accelerates PCP

[90]

2004

APOBEC3G

H186R

Recessive

Accelerates AIDS

[91]

2004

DCSIGN

-336T

Dominant

Decreases infection

[92]

2006

HLA

B27

Co-dominant

Delays AIDS

[93]

2006

TSG101

Hap2

Dominant

Accelerates AIDS

[94]

2006

TRIM5

Hap4

Dominant

Increases infection

[95]

2007

CUL5

HapI

Co-dominant

Accelerates CD4 loss

[96]

2007

PP1A (cyclophilin A)

SNP-4

Dominant

Accelerates AIDS

[97]

2007

HLA

Bw4

Dominant

Reduces HIV

[98]

Transmission

2008

MYH9

End Stage Renal Disease

[31]

2008

MYH9

HIV FSGN

[30]

2008

mtDNA

Hap-J, U5a

Dominant

Accelerates AIDS

[56]

2008

mtDNA

Hap-H

Dominant

Increases

[55]

Lipoatrophy post

HAART

2008

mtDNA

Hap-J

Dominant

Delays CMV-NRD

[99]

2009

HCP5

T>G; rs2395029

Dominant

HIV set point

[33]

2009

HLA

rs9264942

Dominant

HIV set point

[33]

2009

PROX1

Hap-CGT

Recessive

Delays AIDS progression

[37]

2009

APOBEC 3B

ΔV_

Recessive

Increases infection

[100]

2010

PECI

G

Dominant

Accelerates AIDS

[52]

2010

ACSM4

A

Co-dominant

Delays AIDS

[52]

2010

NCOR2

T

Dominant

Increases infection

[57]

2010

IDH1

C

Dominant

Prevents infection

[57]


All these genes were discovered or validated using the NCI-Laboratory of Genomic Diversity. Eight AIDS cohorts comprising more than 10,000 study participants were used in these studies from 1985 to 2011 [5,10,79,101].

O'Brien and Hendrickson Genome Biology 2013 14:201   doi:10.1186/gb-2013-14-1-201