Regulation of transcripts by a DNA methyltransferase inhibitor in in vitro cultured human tubular epithelial cells. Gene ontology terms of transcripts showing differential expression in the decitabine-treated cells. (A) Illustration of regions that showed differential methylation of cultured HKC8 cells treated with 0.5 μM decitabine (5'DAC). CTL, control. (B) The interconnected network analysis highlighted the differential expression of cell adhesion and developmental pathways. These genes are also differentially expressed and methylated in the original CKD dataset. GO, gene ontology.
Ko et al. Genome Biology 2013 14:R108 doi:10.1186/gb-2013-14-10-r108