Additional file 10: Figure S6.
Hypothetical model for condensin binding. Condensins are recruited to chromosomes at sites specified by DNA sequence motifs (colored boxes). These motifs may be recognized by recruiters and cofactors that can interact with condensins. For example, condensin IDC is able to interact with X-specific condensin recruiters, but not autosomal recruiters. There exists more than one condensin recruiter, since SDC-2 is required to bring condensin II to condensin IDC sites on the X chromosome but condensin II is independently recruited to autosomes. After recruitment, condensins spread onto nearby chromatin (indicated by arrows). For condensin IDC, at least 88% of the approximately 1,600 binding sites on the X are predicted to arise from spreading. The potential role of why SCC-2 is also recruited to the condensin IDC binding sites by SDC-2 is not clear.
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Kranz et al. Genome Biology 2013 14:R112 doi:10.1186/gb-2013-14-10-r112