Age acceleration versus number of somatic mutations in the TCGA data. Mutation data from TCGA were used to count the number of mutations per cancer sample. (A) Age acceleration versus (log transformed) mutation count per sample across all cancers. Note that this analysis is confounded by cancer/tissue type. (B-P) A significant negative relationship between age acceleration and number of somatic mutations can be observed in the following seven affected tissues/cancers: (C) bone marrow (AML), (D) breast carcinoma (BRCA), (G) kidney (KIRC), (H) kidney (KIRP), (K) ovarian cancer (OVAR), (L) prostate (PRAD), and (O) thyroid (THCA). No significant relationship could be found in the following six cancer types: (F) colon carcinoma (COAD), (I) lung adenocarcinoma (LUAD), (J) lung squamous cell carcinoma (LUSC), (P) uterine endometrioid, (M) rectal cancer (READ), (N) skin. Due to the low sample size, the results are inconclusive for (B) bladder cancer and (E) cervical cancer. Each point corresponds to a DNA methylation sample (cancer sample from a human subject) analogous to Additional file 12. The x-axis reports the log transformed (base 10) number of mutations observed per sample. The figure titles report the biweight midcorrelation, which is a robust measure of correlation.
Horvath Genome Biology 2013 14:R115 doi:10.1186/gb-2013-14-10-r115