Additional file 14.

Age acceleration versus tumor grade and stage. Panels correspond to the cancer data sets described in Additional file 12. Nominally significant negative correlations between grade and age acceleration can be observed in ovarian serous cystadenocarcinoma (panel G; P = 0.032) and uterine corpus endometroids (panel J; P = 0.019). A nominally significant positive correlation between stage and age acceleration can be observed for colon adenocarcinoma (panel O; P = 0.021). Only the highly significant negative correlation between stage and age acceleration in thyroid cancer (panel Z; P = 8.7E-9) remains significant after adjusting for multiple comparisons. Since grade and stage are often considered as ordinal variables, correlation test P-values are reported in all panels except the last. (H) For prostate cancer, the x-axis reports the Gleason sum score. The last panel shows that mean age acceleration in acute myeloid leukemia is not significantly related to French American British (FAB) morphology but some groups (notably M6 and M7) are very small (rotated grey numbers).

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Horvath Genome Biology 2013 14:R115   doi:10.1186/gb-2013-14-10-r115