Additional file 17.

Effect of TP53 mutation on age acceleration. Mutations in TP53 are associated with significantly lower age acceleration in five cancers: including AML (P = 0.0023), breast cancer (P = 1.4E-5 and P = 3.7E-8), ovarian serous cystadenocarcinoma (P = 0.03) (I), and uterine corpus endometrioid (P = 0.00093). Marginally significant results could be observed in lung squamous cell carcinoma (P = 0.047 for the 27K data but insignificant results for the 450K data).

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Horvath Genome Biology 2013 14:R115   doi:10.1186/gb-2013-14-10-r115