Additional file 2.
Materials and methods supplement. This document has the following sections: Limitations; Description of the healthy tissue and cell line data sets; Criteria guiding the choice of the training sets; Description of the cancer data sets; DNAm profiling and pre-processing steps; Normalization methods for the DNA methylation data; Explicit details on the definition of DNAm age; Chromatin state data used for Additional file 9; Comparing the multi-tissue predictor with other age predictors; Meta analysis for finding age-related CpGs; Variation of age related CpGs across somatic tissues; Studying age effects using gene expression data; Meta-analysis applied to gene expression data; Names of the genes whose mutations are associated with age acceleration; Is DNAm age a biomarker of aging?
Format: DOCX Size: 159KB Download file
Horvath Genome Biology 2013 14:R115 doi:10.1186/gb-2013-14-10-r115