Additional file 4.

Age predictions in blood data sets. (A) DNAm age has a high correlation with chronological age (y-axis) across all blood data sets. (B-S) Results for individual blood data sets. The negligible age correlation in panel 0) reflects very young subjects that were either zero or 0.75 years (9 months) old. (S) DNAm age in different cord blood data sets (x-axis). Bars report the mean DNAm age (±1 standard error). The mean DNAm age in data sets 6 and 50 is close to its expected value (zero) and it is not significantly different from zero in data set 48. (T) Mean DNAm age across whole blood, peripheral blood mononuclear cells, granulocytes as well as seven isolated cell populations (CD4+ T cells, CD8+ T cells, CD56+ natural killer cells, CD19+ B cells, CD14+ monocytes, neutrophils, and eosinophils) from healthy male subjects [82]. The red vertical line indicates the average age across subjects. No significant difference in DNAm age could be detected between these groups, but note the relatively small group sizes (indicated by the grey numbers on the y-axis).

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Horvath Genome Biology 2013 14:R115   doi:10.1186/gb-2013-14-10-r115