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Fixated on fixation: using ChIP to interrogate the dynamics of chromatin interactions

Leeat Keren12 and Eran Segal12*

Author Affiliations

1 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel

2 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel

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Genome Biology 2013, 14:138  doi:10.1186/gb4139

Published: 21 November 2013

Abstract

A new study exploits the time-dependence of formaldehyde cross-linking in the commonly used chromatin immunoprecipitation (ChIP) assay to infer the on and off rates for site-specific chromatin interactions.