Figure 4.

plncRNA but not elncRNA loci are selectively constrained over rodent evolution. (A) Mouse-rat nucleotide substitution rate for elncRNA TIRs (median delncRNA-TIR = 0.161, green) and plncRNA TIRs (median dplncRNA-TIR = 0.127, blue), and for neighboring putatively neutrally evolving sequence (ancestral repeats (ARs), white). Horizontal dashed line represents the neutral expectation (median dAR = 0.165). (B) Mouse-rat nucleotide substitution rate for elncRNA loci (delncRNA-loci = 0.166, green) and plncRNA loci (dplncRNA-loci = 0.159, blue), and ARs (white). (C) Mouse-rat nucleotide substitution rate for transcribed and spliced plncRNA exons (dplncRNA-exon = 0.156, violet) and plncRNA introns (dplncRNA-intron = 0.165, turquoise), and ARs (white). Two-tailed Mann–Whitney test, ***P < 0.001; **P < 0.01; *P < 0.05; NS, not significant.

Marques et al. Genome Biology 2013 14:R131   doi:10.1186/gb-2013-14-11-r131
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