Additional file 14.

plncRNA but not elncRNA loci are selectively constrained over mammalian evolution. (A) Mouse-human nucleotide substitution rates for protein-coding (PC) transcriptional initiation regions (TIRs), lncRNA TIRs and neighboring putatively neutrally evolving sequence (ancestral repeats, ARs). (B) Mouse-human nucleotide substitution rates for transcribed loci of protein-coding genes (PC) and lncRNAs and for ARs. (C) Mouse-human nucleotide substitution rates for elncRNA and plncRNA TIRs. (D) Mouse-human nucleotide substitution rates for elncRNA and plncRNA transcribed loci. ***P < 0.001; **P < 0.01; *P < 0.05; NS, not significant.

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Marques et al. Genome Biology 2013 14:R131   doi:10.1186/gb-2013-14-11-r131