Additional file 5.
Contrasting epigenetic landscapes at transcriptional start sites of promoter or enhancer-associated lncRNAs in mouse intermediate erythroblasts. (A) All detected mouse erythroid DNAse I hypersensitive sites (DHSs) were sorted based on the difference in enrichment of H3K4me1 and H3K4me3. The same sort order was used for all panels displayed here, and levels of H3K4me3 and H3K4me1 are depicted as red and blue triangles, respectively. Each panel shows the distribution of signal in a 4 kb window centered on the middle of each DHS. The enhancer and promoter populations are demarcated by blue and red boxes, respectively. The active chromatin mark H3K27ac and NanoCage mapped sources of transcription are associated with both the enhancer and promoter populations, whereas the signal for the tissue-specific transcription factor Gata1 is predominately associated with the enhancer class as expected. (B,C) Chromatin profiles normalized for number of peaks associated with the mouse Ter119+ promoters and enhancers, respectively. (D,E) Chromatin profiles normalized for number of peaks associated with the mouse Ter119+ plncRNAs and elncRNAs TIRs, showing their promoter and enhancer profiles, respectively. Color coding indicating each chromatin mark is shown below.
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Marques et al. Genome Biology 2013 14:R131 doi:10.1186/gb-2013-14-11-r131