Additional file 1: Figure S1.

Regions of association defined with LD clumping. Figure S2. Ages of affected and unaffected samples. Figure S3. Phenotype variance explained at different association thresholds. Figure S4. The difference in genotype relative risk between cases and controls persists at more stringent significance thresholds. Figure S5. Cross-breed meta-analysis of OS GWAS datasets. Figure S6. Transcription factor motif analysis of top candidate variant. Figure S7. Size distribution of fixed and RRV regions by breed. Figure S8. CGH penetrance plots of dog and human OS. Figure S9. Dog GWAS results in human OS associated regions. Figure S10. Confidence interval comparison. Table S1. Association at top SNPs when sex is included as a covariate in the EMMAX genomewide analysis. Table S2. Top associated variants in the greyhound finemapping and imputation analysis. Table S3. Meta-analysis of nine breeds at the top candidate variant. Table S4. GRAIL keywords over-represented among genes in more than one osteosarcoma GWAS region. Table S5. Association between top GWAS SNPs and CGH gain/loss in matched germline tumor samples, controlling for breed clusters using Cochran-Mantel-Haenszel (CMH) test. Table S6. Osteosarcoma related microRNA sets curated from literature for INRICH testing.

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Karlsson et al. Genome Biology 2013 14:R132   doi:10.1186/gb-2013-14-12-r132