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A CRISPR way to engineer the human genome

Sivaprakash Ramalingam, Narayana Annaluru and Srinivasan Chandrasegaran*

Author Affiliations

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, 615 North Wolfe Street, Baltimore, MD 21205, USA

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Genome Biology 2013, 14:107  doi:10.1186/gb-2013-14-2-107

Published: 26 February 2013

Abstract

RNA-guided genome engineering based on the type II prokaryotic CRISPR/Cas system provides an efficient and versatile method for targeted manipulation of mammalian genomes.