Nutrient deprivation induces widespread but distinct RBP-crosslinking and mRNA changes. (a,b) Changes in 3' UTR crosslinking site coverage upon glucose (a) or nitrogen (b) starvation. Standard deviations of intra-replicate variation: wild-type (WT), 1.31-fold; glucose starvation, 1.24-fold; nitrogen starvation, 1.15-fold. (c) Overlap of 3' UTR crosslinking site changes affected by glucose or nitrogen starvation conditions. (d,e) Global changes in mRNA abundance upon glucose (d) or nitrogen (e) starvation. (f) Overlap of mRNAs with 3' UTR crosslinking site changes affected by glucose or nitrogen starvation conditions. (g,h) Enriched Gene Ontology terms for mRNAs with 3' UTR crosslinking sites with decreased (g) or increased (h) RBP occupancy upon glucose or nitrogen starvation or both. Grey lines indicate P-value of 0.05.
Freeberg et al. Genome Biology 2013 14:R13 doi:10.1186/gb-2013-14-2-r13