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The fractured genome of HeLa cells

David Mittelman12* and John H Wilson3

Author Affiliations

1 Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24060, USA

2 Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24060, USA

3 Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

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Genome Biology 2013, 14:111 doi:10.1186/gb-2013-14-4-111

Published: 17 April 2013

Abstract

Whole-genome sequencing of the widely used HeLa cell line provides a nucleotide-resolution view of a greatly mutated and in some places shattered genome.

Keywords:
HeLa cells; high-throughput sequencing; genome instability; cell line identification; tandem repeats