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Highly Accessed Review

Neurogenomics of speech and language disorders: the road ahead

Pelagia Deriziotis1 and Simon E Fisher12*

Author Affiliations

1 Max Planck Institute for Psycholinguistics, 6525 XD Nijmegen, The Netherlands

2 Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, The Netherlands

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Genome Biology 2013, 14:204 doi:10.1186/gb-2013-14-4-204

Published: 18 April 2013

Abstract

Next-generation sequencing is set to transform the discovery of genes underlying neurodevelopmental disorders, and so offer important insights into the biological bases of spoken language. Success will depend on functional assessments in neuronal cell lines, animal models and humans themselves.

Keywords:
exome; genome; FOXP2; functional validation; language; next-generation sequencing; neurodevelopmental disorders; speech