Table 2

Gene Ontology enrichment analysis of immune cluster genes.

Gene Ontology term

%1

Univariate P-value2

FDR-adjusted P-value3


B/P Cluster

Immunoglobulin

34.5

4.6E-25

1.8E-23

Immunoglobulin V-set

37.9

2.6E-18

2.5E-17

Antigen binding

27.6

8.7E-16

1.2E-14

Immunoglobulin-like fold

44.8

9.7E-16

4.8E-15

Immune response

41.4

2.0E-13

2.6E-11

T/NK

Cluster

Positive regulation of immune system process

24.4

1.7E-08

2.5E-05

Natural killer cell mediated cytotoxicity

19.5

9.7E-07

5.9E-05

Positive regulation of lymphocyte activation

17.1

3.3E-07

6.9E-05

T cell

12.2

1.3E-06

7.2E-05

Positive regulation of lymphocyte differentiation

12.2

3.7E-06

3.3E-04

M/D Cluster

MHC class II, alpha/beta chain, N-terminal

39.1

7.0E-22

3.4E-20

Class II histocompatibility antigen

39.1

1.3E-19

1.9E-18

MHC class II protein complex

39.1

4.6E-20

3.3E-18

Immunoglobulin C1-set

43.5

7.0E-18

1.7E-16

Antigen processing and presentation

47.8

1.3E-18

3.0E-16


1percentage of cluster genes (relative to all genes on array) annotated for a given ontology term; 2modified Fisher's Exact Test; 3Benjamini and Hochberg false discovery rate-adjusted P-value. B/P: B cell/plasma cell cluster; M/D: monocytes and dendritic cell cluster; T/NK: T cell and natural killer cell cluster.

Nagalla et al. Genome Biology 2013 14:R34   doi:10.1186/gb-2013-14-4-r34

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