Table 4

Univariable and multivariable survival analysis with immune metagenes and conventional variables in the high proliferation tertile.

PH (n = 421)

Univariable

Multivariable

Variables

Hazard ratio

(95% CI)7

P-value8

Hazard ratio

(95% CI)

P-value


B/P (L, I, H)1

0.55 (0.45 to 0.66)

< 0.0001

0.59 (0.45 to 0.78)

0.0001

M/D (L, I, H)

0.62 (0,51 to 0.75)

< 0.0001

0.89 (0.65 to 1.21)

0.45

T/NK (L, I, H)

0.62 (0.51 to 0.75)

< 0.0001

0.98 (0.71 to 1.35)

0.9

LN Status (-,+)2

1.38 (0.99 to 1.94)

0.06

1.75 (1.12 to 2.74)

0.01

Tumor Size (T1, T2, T3)3

1.37 (1.02 to 1.85)

0.04

1.44 (1.05 to 1.97)

0.02

Histologic Grade (1,2,3)4

0.72 (0.54 to 0.95)

0.02

0.80 (0.59 to 1.08)

0.14

Age (≤ 40 yrs, > 40 yrs)5

1.26 (0.83 to 1.91)

0.28

1.19 (0.73 to 1.72)

0.61

ER Status (+,-)6

0.68 (0.49 to 0.96)

0.03

0.87 (0.60 to 1.26)

0.46

Systemic Treatment (no, yes)

1.02 (0.74 to 1.41)

0.89

1.56 (1.02 to 2.39)

0.04


1metagene tertiles (L: low; I: intermediate; H: high); 2lymph node status (negative or positive); 3tumor size by American Joint Committee on Cancer criteria (T1 ≤ 2 cm, T2 > 2 cm but ≤ 5 cm, T3 > 5 cm); 4Nottingham histologic grade (1: well differentiated, 2: moderately differentiated, 3: poorly differentiated); 5 age at diagnosis; 6 estrogen receptor status (positive or negative); 7 95% confidence interval; 8 likelihood ratio test. B/P: B cell/plasma cell metagene; M/D: monocytes and dendritic cell metagene; T/NK: T cell and natural killer cell metagene.

Nagalla et al. Genome Biology 2013 14:R34   doi:10.1186/gb-2013-14-4-r34

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