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Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine

Sean M Cullen and Margaret A Goodell*

Author Affiliations

Stem Cells and Regenerative Medicine Center & Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA

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Genome Biology 2013, 14:116 doi:10.1186/gb-2013-14-5-116

Published: 28 May 2013

Abstract

The differentiation of intestinal stem cells involves few DNA methylation changes, assayed by bisulfite sequencing, in contrast to other adult somatic stem cell hierarchies.

Please see related Research article: http://genomebiology.com/2013/14/5/R50 webcite

Keywords:
DNA methylation; Somatic stem cell differentiation; Lgr5; WGBS; Intestinal stem cell