Open Access Highly Accessed Research

Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance

David Martino1, Yuk Jin Loke23, Lavinia Gordon4, Miina Ollikainen5, Mark N Cruickshank26, Richard Saffery13† and Jeffrey M Craig23*†

1 Cancer, Disease and Developmental Epigenetics, Murdoch Childrens Research Institute (MCRI), Flemington Road, Parkville, Victoria 3052, Australia

2 Early Life Epigenetics Group, MCRI, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia

3 Department of Paediatrics University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia

4 Bioinformatics Unit, MCRI, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia

5 Hjelt Institute, Department of Public Health, University of Helsinki, Mannerheimintie 172, 00300 Helsinki, Finland

6 Current address: Division of Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Centre for Child Health, University of Western Australia, 100 Roberts Road, Subiaco, Western Australia 6008, Australia

For all author emails, please log on.

Genome Biology 2013, 14:R42 doi:10.1186/gb-2013-14-5-r42

Published: 22 May 2013

Additional files

Additional file 1:

Supplementary figures and legends.

Format: PDF Size: 694KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Supplementary tables and legends.

Format: XLSX Size: 471KB Download file

Open Data