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Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance

David Martino1, Yuk Jin Loke23, Lavinia Gordon4, Miina Ollikainen5, Mark N Cruickshank26, Richard Saffery13 and Jeffrey M Craig23*

Author Affiliations

1 Cancer, Disease and Developmental Epigenetics, Murdoch Childrens Research Institute (MCRI), Flemington Road, Parkville, Victoria 3052, Australia

2 Early Life Epigenetics Group, MCRI, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia

3 Department of Paediatrics University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia

4 Bioinformatics Unit, MCRI, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia

5 Hjelt Institute, Department of Public Health, University of Helsinki, Mannerheimintie 172, 00300 Helsinki, Finland

6 Current address: Division of Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Centre for Child Health, University of Western Australia, 100 Roberts Road, Subiaco, Western Australia 6008, Australia

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Genome Biology 2013, 14:R42  doi:10.1186/gb-2013-14-5-r42

Published: 22 May 2013

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