Table 6

Genome-wide DNA methylation studies for birth weight

Study

Design

Sample

Tissue

Method

Significant loci

Remark


Einstein et al. [16]

Population based

5 IUGR and 5 AGA

CD34+ hematopoietic stem cells (cord blood)

HELP

56 loci (P < 0.00001)

Banister et al. [37]

Population based

89 IUGR and 117 AGA

Placenta

HM27

22 loci (number predetermined)

Fryer et al. [34]

Population based

12 newborns

Cord blood

HM27

304 loci (P < 0.05)

Samples were selected to give a range in LINE1 methylation values

Adkins et al. [36]

Population based

201 newborns

Cord blood

HM27

10 loci (P < 0.001)

Turan et al. [35]

Population based

48 newborns

Cord blood and placenta

HM27

23 loci

Regularized regression model fit was used (R2 > 0.80)

Gordon et al. [38]

Twin design

18 MZ and 10 DZa

CBMCs, placenta and UVECs

HM27

7 loci in DZ CBMCs

1 loci in MZ UVECs (FDR <0.1)

Twins not selected for birth weight discordancy


aMaximal 18 MZ and 10 DZ twins per tissue. AGA, appropriate for gestational age; CBMC, cord blood mononuclear cell; DZ, dizygotic twin; FDR, false discovery rate; HELP, HpaII tiny fragment Enrichment by Ligation-mediated PCR assay; HM27, HumanMethylation27 BeadChip; IUGR, intra-uterine growth retarded; MZ, monozygotic twins; UVEC, umbilical vascular endothelial cell.

Souren et al. Genome Biology 2013 14:R44   doi:10.1186/gb-2013-14-5-r44

Open Data