Table 6 |
||||||
|
Genome-wide DNA methylation studies for birth weight |
||||||
|
Study |
Design |
Sample |
Tissue |
Method |
Significant loci |
Remark |
|
|
||||||
|
Einstein et al. [16] |
Population based |
5 IUGR and 5 AGA |
CD34+ hematopoietic stem cells (cord blood) |
HELP |
56 loci (P < 0.00001) |
|
|
Banister et al. [37] |
Population based |
89 IUGR and 117 AGA |
Placenta |
HM27 |
22 loci (number predetermined) |
|
|
Fryer et al. [34] |
Population based |
12 newborns |
Cord blood |
HM27 |
304 loci (P < 0.05) |
Samples were selected to give a range in LINE1 methylation values |
|
Adkins et al. [36] |
Population based |
201 newborns |
Cord blood |
HM27 |
10 loci (P < 0.001) |
|
|
Turan et al. [35] |
Population based |
48 newborns |
Cord blood and placenta |
HM27 |
23 loci |
Regularized regression model fit was used (R2 > 0.80) |
|
Gordon et al. [38] |
Twin design |
18 MZ and 10 DZa |
CBMCs, placenta and UVECs |
HM27 |
7 loci in DZ CBMCs 1 loci in MZ UVECs (FDR <0.1) |
Twins not selected for birth weight discordancy |
|
|
||||||
|
aMaximal 18 MZ and 10 DZ twins per tissue. AGA, appropriate for gestational age; CBMC, cord blood mononuclear cell; DZ, dizygotic twin; FDR, false discovery rate; HELP, HpaII tiny fragment Enrichment by Ligation-mediated PCR assay; HM27, HumanMethylation27 BeadChip; IUGR, intra-uterine growth retarded; MZ, monozygotic twins; UVEC, umbilical vascular endothelial cell. |
||||||
|
Souren et al. Genome Biology 2013 14:R44 doi:10.1186/gb-2013-14-5-r44 |
||||||
