High resolution ChIP-seq mapping at known Sir2, Hst1, and Sum1 targets. (a) Sir2 enrichment at the HML. Locations of the E and I silencers are indicated. (b) Sir2 enrichment at the HMR. The right boundary element tRNAThr gene is indicated as tT(AGU)C. Locations of the E and I silencers are indicated. (c) Sir2, Hst1, and Sum1 enrichment at the BNA2 and SPS4 promoters. (d) Sir2 enrichment at the rDNA repeats on chromosome XII. The left-most and right-most repeats annotated in the SGD genome assembly are displayed, but the read counts in brackets are a compilation from all approximately 175 repeats. The 5S genes within the intergenic spacers are indicated as RDN5-1 and RDN5-2, and define the right end of each repeat.
Li et al. Genome Biology 2013 14:R48 doi:10.1186/gb-2013-14-5-r48