Table 1

Dataset of known, candidates and mutated cancer genes

Cancer type

Known cancer genes

Candidate cancer genes

Rest of mutated genes

Tumour samples

References


Bladder

24

9

380

97

[8]


Breast

165

280

1,520

196

[2,11,40,52]


Colorectal

42

124

654

11

[2]


Gastric

203

14

5,160

109

[16]


Glioblastoma

127

87

1,679

197

[5,12,39]


HNSCC

221

67

5,901

194

[15,35]


Kidney

71

15

655

517

[7,9,55]


Leukaemia

58

169

877

393

[18,41,44,46,50,51]


Liver

26

66

370

140

[45,53]


Lung

218

143

1,012

324

[4,11,43,49]


Lymphoma

46

47

574

133

[14,47]


Medulloblastoma

16

1

194

88

[13]


Melanoma

96

159

2,845

16

[17,48,54]


Myelodysplasia

22

4

206

29

[57]


Myeloma

69

6

1,260

37

[6]


Oligodendroglioma

12

0

149

34

[38]


Ovarian

60

80

109

58

[11]


Pancreas

77

194

1,070

205

[10,11,42,56]


Prostate

54

161

81

67

[11,37]


Sarcoma

11

10

0

207

[36]


Total

444

608

9,629

3,052

NA


Starting from 10,681 human genes with at least one cancer-specific non-synonymous mutation, three groups were identified: known cancer genes that are part of the cancer gene census [58]; candidate genes that are likely to play a role in cancer because they are recurrently mutated; and the rest of mutated genes that carry at least one non-synonymous mutation. The full description of mutated genes in each of the 39 sequencing screenings is reported in Additional file 2, Table S1. HNSCC; head and neck squamous cell carcinoma.

D'Antonio and Ciccarelli Genome Biology 2013 14:R52   doi:10.1186/gb-2013-14-5-r52

Open Data