Table 2

Putative novel drivers in ovarian cancer

Ovarian carcinoma sample

Gene

Ovarian cell lines with increased proliferation

Pathway/Biological process

Reference


TCGA-04-1525

SETDB1

NA

PI3K/RAS

[95]


SIPA1L1

NA

Cytoskeleton organisation

[96]


TCGA-09-2051

SPTLC1

1

MYC

[97]


TCGA-10-0927

GTF3

10

RB

[98]


SQRDL

1

Amino acid metabolism

[99]


TCGA-13-0717

GRIT

NA

JNK/MAPK

[100]


TCGA-13-0755

ANXA2

2

Vesicle transport

[101]


FBLN1

1

Cell adhesion

[97]


FEN1

4

DNA repair

[102]


GSS

3

Glutathione metabolism

[103]


KDM5B

14

RB

[104]


MBNL1

3

Splicing regulation

[105]


PKP4

NA

WNT

[106]


U2SURP

NA

WNT

[97]


WDR61

NA

Chromatin regulation

[107]


TCGA-13-1408

F11R

0

Cell adhesion

[108]


PELI1

NA

PI3K/RAS

[109]


PTPRG

23

WNT

[110]


TAF12

18

Transcriptional activation

[111]


TIAM1

25

JNK/MAPK

[112]


TCGA-13-1506

BTBD2

NA

NF-kB (transcription)

[113]


TCGA-13-1510

RIOK3

7

Unknown

NA


TCGA-23-1024

FAM59A

NA

JNK/MAPK

[114]


PBX2

22

Transcriptional activation

[115]


TCGA-24-1431

ANKZF1

NA

Unknown

NA


ATP1B1

0

Ion transport

[116]


TCGA-24-1544

CCDC93

10

Unknown

NA


HDAC6

1

Chromatin regulation

[117]


TCGA-24-1546

SUGP1

7

Splicing regulation

[99]


VAV1

14

JNK/MAPK

[118]


TCGA-24-1567

HTATSF1

5

Splicing regulation

[119]


INADL

NA

Cell-cell interactions

[120]


KAL1

0

Cell adhesion

[121]


RAGEF2

25

JNK/MAPK

[122]


TCGA-25-1623

PSD3

NA

Transcriptional activation

[123]


TCGA-25-1627

KAT2B

9

WNT

[124]


PIK3R4

1

PI3K/RAS

[125]


TTF2

25

Transcriptional repression

[126]


TCGA-25-1630

APEX1

9

DNA repair

[127]


ATG3

NA

Autophagy

[128]


CAT

2

PI3K/RAS

[129]


DCAF6

NA

Transcriptional activation

[130]


TCGA-25-1633

SASH3

0

Antigen receptor signalling

[131]


TCGA-25-1634

GSN

5

TP53

[132]


MCM4

15

G1/S transition

[133]


RBL2

25

RB

[134]


TCGA-25-2391

RASA1

5

PI3K/RAS

[135]


TCGA-25-2393

ANO1

0

Ion transport

[131]


FUT1

1

Antigen synthesis

[136]


MCM4

15

G1/S transition

[137]


PRKCQ

22

PI3K/RAS

[138]


RB1CC1

8

RB

[121]


ZC3H14

NA

Translation

[139]


TCGA-36-1570

PSD3

NA

Transcriptional activation

[140]


TCGA-36-1574

NRCAM

NA

Cell adhesion

[141]


NSMAF

NA

NF-kB (transcription)

[142]


PASK

24

Translation

[143]


TCGA-36-1577

PRKD1

1

Transcriptional activation

[144]


Shown are 23 ovarian carcinomas hosting 58 putative driver mutations in 56 genes. Two genes (MCM4 and PSD3) were mutated in two tumours. For 40 genes with available RNAi data [71], the number of ovarian cell lines where an increased in cell growth was observed upon gene silencing is shown. Thirteen carcinomas (57% of the total) bear mutations in pathways previously associated with ovarian cancer, and six of them (26% of the total) had alterations in transcription-related pathways. A detailed description of the effects of each mutation is shown in Additional file 2, Table S7.

D'Antonio and Ciccarelli Genome Biology 2013 14:R52   doi:10.1186/gb-2013-14-5-r52

Open Data