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DNA methylation, genotype and gene expression: who is driving and who is along for the ride?

Meaghan J Jones1, Anthony P Fejes1 and Michael S Kobor12*

Author Affiliations

1 Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, BC, V5Z 4H4, Canada

2 Human Early Learning Partnership, School of Population and Public Health, University of British Columbia, BC, V6T 1Z3, Canada

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Genome Biology 2013, 14:126  doi:10.1186/gb-2013-14-7-126

Published: 29 July 2013

Abstract

A new study integrates genome-wide SNP genotyping, RNA-Seq and DNA methylation in human cells, revealing their relationships and posing new questions about causality.