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Gene expression changes with age in skin, adipose tissue, blood and brain

Daniel Glass12, Ana Viñuela1, Matthew N Davies1, Adaikalavan Ramasamy3, Leopold Parts4, David Knowles5, Andrew A Brown4, Åsa K Hedman6, Kerrin S Small14, Alfonso Buil7, Elin Grundberg14, Alexandra C Nica7, Paola Di Meglio8, Frank O Nestle8, Mina Ryten3, the UK Brain Expression consortium1, the MuTHER consortium, Richard Durbin4, Mark I McCarthy69, Panagiotis Deloukas4, Emmanouil T Dermitzakis7, Michael E Weale3, Veronique Bataille1* and Tim D Spector1*

Author Affiliations

1 Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, Westminster Bridge Road, London SE1 7EH, UK

2 North West London Hospitals NHS Trust, Northwick Park Hospital, Watford Road, Harrow HA1 3UJ, UK

3 Department of Medical ƒ Molecular Genetics, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK

4 Wellcome Trust Sanger Institute, HinxtonCB10 1SA,UK

5 Stanford University, 450 Serra MallStanford, CA 94305, USA

6 Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK

7 Department of Genetic Medicine and Development, University of Geneva Medical School, 1 Rue Michel-Servet (CMU office 9088), Geneva 1211, Switzerland

8 St. John's Institute of Dermatology, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK

9 Oxford Centre for Diabetes, Endocrinology ƒ Metabolism, University of Oxford, Churchill Hospital, Oxford, Headington OX3 7LJ,UK

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Genome Biology 2013, 14:R75  doi:10.1186/gb-2013-14-7-r75

Published: 26 July 2013

Additional files

Additional file 1:

Table S1:Age for individuals with microarray expression in skin, adipose tissue, and LCLs.

Format: TXT Size: 24KB Download file

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Additional file 2:

Table S2: Pvalues for ageeffect in skin tissue.

Format: TXT Size: 1.7MB Download file

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Additional file 3:

Table S3: Pvalues for ageeffect in adipose tissue.

Format: TXT Size: 1.7MB Download file

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Additional file 4:

Table S4:List of genes with age effect in skin and adipose tissue included in the GenAge database [6].

Format: CSV Size: 13KB Download file

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Additional file 5:

Table S5: Pvalues for ageeffect in LCLs.

Format: TXT Size: 1.4MB Download file

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Additional file 6:

Table S6: Pvalues for ageeffect in fresh lymphocytes.

Format: TXT Size: 1.7MB Download file

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Additional file 7:

Figure S1:Pvalues distribution for age effect analysis in 777 individuals with lymphocytes cell lines (LCLs) and 92 individuals with fresh lymphocytes expression arrays.

Format: TIFF Size: 607KB Download file

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Additional file 8:

Figure S2: Pvalues distribution for age effect analysis in 40 individuals with both lymphocytes cell lines (LCLs) and fresh lymphocytes expression profiles.

Format: TIFF Size: 602KB Download file

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Additional file 9:

Figure S3: Beta values from lymphocytes cell lines (LCLs) and fresh lymphocytes expression association with age in 40 common samples (left) and in whole dataset (777 LCL and 92 fresh lymphocytes) (right).

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Additional file 10:

Table S7: Pvalues for ageeffect in brain.

Format: TXT Size: 543KB Download file

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Additional file 11:

Table S8: Pvalues for genotype-by-age interactions in skin tissue.

Format: CSV Size: 129KB Download file

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Additional file 12:

Table S9: Pvalues for genotype-by-age interactions in adipose tissue.

Format: CSV Size: 158KB Download file

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Additional file 13:

TableS10: List of contributors to the MuTHER and the UK Brain Expression Consortiums.

Format: DOCX Size: 13KB Download file

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