Resolution:
## Figure 4.
Sign epistasis is less likely to occur between mutations with large effects. (a) Examples of a smooth landscape with paths of monotonically increasing fitness (left)
and a rugged landscape characterized by reciprocal sign epistasis (right). (b) Experimentally measured probability of observing sign epistasis as a function of the
log growth of two single knockouts with similar effects (G_{01 }= G_{10 }within 20%, G = mean(G_{01}, G_{10})). The blue shaded area is the standard error of the mean computed by bootstrap.
Velenich and Gore |