Table 2

Gene Ontology terms associated with temporal gene expression profiles during encystation

Profile/clustera

GO category name

Fold enrichmentb

Corrected P-valuec


Profile 16

Translation

7.8

<0.001

Structural constituent of ribosome

7.9

<0.001

Ribosome

8.1

<0.001

Protein binding

2.9

<0.001

Actin binding

4.9

<0.001

Glycolysis

12.2

<0.001

Intracellular

1.7

<0.001

Cytoplasm

4

0.002

Catalytic activity

2.3

0.002

Oxidoreductase activity

3.4

0.002

Oxidation-reduction process

4

0.038

Profile 15

Translation

12.1

<0.001

Structural constituent of ribosome

11.8

<0.001

Ribosome

11

<0.001

Small ribosomal subunit

24.3

<0.001

Intracellular

2.2

<0.001

Aminoacyl-tRNA ligase activity

16.6

<0.001

tRNA aminoacylation for protein translation

16.6

<0.001

Cytoplasm

6.5

<0.001

NAD binding

16.5

<0.001

Metabolic process

3

0.018

Cluster (profiles 24, 41)

Heat shock protein binding

6.7

0.004

Profile 24

Heat shock protein binding

8.5

0.006

Unfolded protein binding

6.3

0.01

Protein folding

5.7

0.014

Cluster (profiles 31, 34)

Metabolic process

3.4

<0.001

Catalytic activity

2.5

<0.001

Binding

2.3

<0.001

Phosphatidylcholine-sterol O-acyltransferase activity

9

0.016

Membrane coat

5.8

0.016

Structural molecule activity

6.8

0.018

Vesicle-mediated transport

3.3

0.04

Profile 31

Metabolic process

3.5

<0.001

Catalytic activity

2.6

<0.001

Binding

2.4

<0.001

Membrane coat

6.8

0.002

Phosphatidylcholine-sterol O-acyltransferase activity

10.5

0.002

Structural molecule activity

7.9

0.002

Vesicle-mediated transport

3.9

0.004

Lipid metabolic process

4.9

0.034

Profile 19

Vesicle-mediated transport

5.1

0.062

Nucleic acid binding

2.2

0.464

Profile 21

Integral to membrane

4.7

0.014

Membrane

4.1

0.038

Profile 20

Hydrolase activity

4

0.014

Cluster (profiles 32 13)

Methionine adenosyltransferase activity

30.5

<0.001

One carbon metabolic process

30.5

<0.001

DNA binding

3.6

<0.001

Nucleosome

12.2

0.002

Nucleus

3

0.002

Nucleosome assembly

8

0.002

Sequence-specific DNA binding

6.9

0.034

Profile 32

Methionine adenosyltransferase activity

48.7

<0.001

One carbon metabolic process

48.7

<0.001

DNA binding

3.8

<0.001

Nucleus

3.3

0.01

Profile 13

Intracellular protein transport

5.3

0.002

Intracellular

2.3

0.002

GTP binding

3.3

0.002

Small GTPase mediated signal transduction

3.1

0.002

Protein transport

3.4

0.004

Nucleocytoplasmic transport

5.6

0.016

GTPase activity

4.3

0.036


aSee Figure 4 and Additional file 1 for profiles/clusters. bRatio of the observed number of genes with associated GO term to the number expected for a profile of the same size. cP-value Bonferroni-corrected for multiple tests.

Ehrenkaufer et al. Genome Biology 2013 14:R77   doi:10.1186/gb-2013-14-7-r77

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