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A blood based 12-miRNA signature of Alzheimer disease patients

Petra Leidinger1†, Christina Backes1†, Stephanie Deutscher1, Katja Schmitt1, Sabine C Mueller1, Karen Frese2, Jan Haas2, Klemens Ruprecht3, Friedemann Paul34, Cord Stähler5, Christoph JG Lang6, Benjamin Meder2, Tamas Bartfai7, Eckart Meese1† and Andreas Keller15*†

Author Affiliations

1 Department of Human Genetics, Saarland University, Kirrbergerstraße, Building 60, 66421 Homburg, Germany

2 Internal Medicine II, Heidelberg University, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany

3 Clinical and Experimental Multiple Sclerosis Research Center, Charité - University Medicine Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany

4 NeuroCure Clinical Research Center, Charité - University Medicine Berlin, Campus Mitte, Charitéplatz 1,10117 Berlin, Germany

5 Siemens Healthcare, Strategy, Hartmannstr. 16, 91052 Erlangen, Germany

6 Neurological Unit, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany

7 Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA

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Genome Biology 2013, 14:R78 doi:10.1186/gb-2013-14-7-r78

Published: 29 July 2013

Additional files

Additional file 1:

Table S1. Table listing the 180 significantly dys-regulated miRNAs (140 unique mature miRNAs).

Format: XLSX Size: 164KB Download file

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Additional file 2:

Figure S1. Heatmap for the 180 miRNAs significantly dys-regulated in AD patients compared to control individuals.

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This file can be viewed with: Adobe Acrobat Reader

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Additional file 3:

Table S2. Table listing all novel mature miRNAs.

Format: XLSX Size: 13KB Download file

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Additional file 4:

Table S3. Table listing patient characteristics and indicates which samples are included in NGS analysis and/or in the RT-qPCR.

Format: XLSX Size: 22KB Download file

Open Data