Table 1

Overview of the blood samples analyzed using NGS and RT-qPCR

Sample group

N

Age (mean ± SD)

Sex (female/male)

MMSE (mean ± SD)

Cohort size

NGS

Cohort size

RT-qPCR


AD

106

72.7(10.4)

53/53

18.9 (3.4)

48

94


Healthy control

22

67.1 (7.5)

11/11

29.3 (1.2)

22

21


Mild cognitive impairment

18

73.9 (6.2)

9/9

25.3 (1.4)

-

18


Multiple sclerosis

16

32.3 (10.7)

12/4

NA

-

16


PD

9

69.7 (9.0)

1/8

25.2 (4.2)

-

9


DEP

15

45.2 (9.1)

0/15

NA

-

15


BD

15

41.9 (13.7)

14/1

29.5 (1.6)

-

15


SCHIZ

14

41.7 (7.9)

1/13

26.1 (4.3)

-

14


AD: Alzheimer disease; BD: bipolar disorder; DEP: major depression; MMSE: Mini-Mental State Exam; NA: not available; NGS: next-generation sequencing; PD: Parkinson's disease; RT-qPCR: quantitative real-time PCR; SCHIZ: schizophrenia.

Leidinger et al. Genome Biology 2013 14:R78   doi:10.1186/gb-2013-14-7-r78

Open Data