Table 4

Results of the over-representation analysis of the predicted target genes of brain-miR-112.

Subcategory

Subcategory alternative name

Expected

Observed

Pvalue (FDR)

Target genes

AD

BD

DEP

PD

SCHIZ

Multiple sclerosis


Neurogenesis

GO:0022008

119.612

31

0.000284421

ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SIX4 COL4A4 DFNB31 DISC1 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A

--

DISC1

--

--

DISC1

--


Neuron differentiation

GO:0030182

103.937

27

0.000801251

ONECUT2 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 COL4A4 DFNB31 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A

--

--

--

--

--

--


Neuron development

GO:0048666

845.125

23

0.00159317

ONECUT2 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RAB11A RPS6KA4 COL4A4 DFNB31 SRF STX3 ADCY1 CDKN1C CNP ENAH LIF ROCK1 RPS6KA3 TFAP2A

--

--

--

--

--

--


Nervous system development

GO:0007399

184.019

37

0.00268227

ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SEMA5B SIX4 COL4A4 DFNB31 DISC1 FGF1 SRF STX3 SULF1 ADCY1 ARHGEF15 CDKN1C CNP ENAH HOXC10 LIF LPHN1 LRP6 MEN1 ROCK1 RPS6KA3 TFAP2A

FGF1

DISC1

--

--

DISC1

--


Neuron projection development

GO:0031175

736.077

19

0.00946322

ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RAB11A RPS6KA4 COL4A4 SRF STX3 ADCY1 CNP ENAH LIF ROCK1 RPS6KA3

--

--

--

--

--

--


Neuron projection

GO:0043005

633.844

16

0.0262424

ALOX5 ANK3 MYLK2 NFIB SLC38A7 DFNB31 DISC1 FRMPD4 GRIA4 SLC6A1 STX3 AAK1 ALDOC ARHGEF15 BACE1 LPHN1

BACE1

DISC1

--

--

DISC1 GRIA4

--


Neurotransmitter:sodium symporter activity

GO:0005328

0.215825

3

0.0330004

SLC6A20 SLC6A1 SLC6A6

--

--

--

--

--

--


Neuron projection morphogenesis

GO:0048812

624.756

15

0.0391162

ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RPS6KA4 COL4A4 ADCY1 CNP ENAH ROCK1 RPS6KA3

--

--

--

--

--

--


Neurotransmitter transporter activity

GO:0005326

0.272621

3

0.0412241

SLC6A20 SLC6A1 SLC6A6

--

--

--

--

--

--


Neuroblast division

GO:0055057

0.0795144

2

0.0412241

FGFR2 LRP6

--

--

--

--

--

--


Forebrain neuroblast division

GO:0021873

0.0795144

2

0.0412241

FGFR2 LRP6

--

--

--

--

--

--


Generation of neurons

GO:0048699

112.797

31

0.000188727

ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SIX4 COL4A4 DFNB31 DISC1 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A

--

DISC1

--

--

DISC1

--


Cell morphogenesis involved in neuron differentiation

GO:0048667

616.805

15

0.0366659

ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RPS6KA4 COL4A4 ADCY1 CNP ENAH ROCK1 RPS6KA3

--

--

--

--

--

--


This table lists interesting Gene Ontology (GO) subcategories with Pvalues <0.05 and FDR adjustment related to nervous system development.

AD: Alzheimer disease; BP: bipolar disorder; DEP: major depression; PD, Parkinson's disease; SCHIZ: schizophrenia

Leidinger et al. Genome Biology 2013 14:R78   doi:10.1186/gb-2013-14-7-r78

Open Data