Resolution:
standard / ## Figure 2.
Comparison of THetA to CNAnorm and ABSOLUTE on simulated mixtures from real sequencing
data. (A) Comparison of true and inferred tumor purity by THetA, CNAnorm and ABSOLUTE on simulated
mixtures of DNA sequencing data from an acute myeloid leukemia sample and a matched
normal sample. Gray dashed line indicates True Purity = Inferred Purity. Below each
plot are the root mean squared errors (RMSEs) for each method. (B) Comparison of the number of copy number aberrations correctly predicted (defined as
50% reciprocal overlap in position and correct integral copy count) by each method
for varying tumor purity and sequence coverage. Num TP is the number of true positive
copy number aberrations predicted. In most cases, THetA outperforms both CNAnorm and
ABSOLUTE. Similar results counting aberrations with correct position (with 50% reciprocal
overlap) but allowing for difference between true and predicted copy number are in
Additional file 1, Figure S7. RMSE: root mean squared error.
Oesper |