Low complexity and disordered regions. (a) Compared to an average human protein, the proteins found in the nucleic acid (NA) interactome contained more residues in low complexity regions (P < 1.7E-11, KS test), a bias similar to what was observed for the mRNA interactome. This bias is augmented for proteins in both interactomes as opposed to proteins in the nucleic acid interactome only (mRNA interactome subtracted), which are mostly non-sequence-specific DNA binders. (b) The same biases are observed for disordered regions. TF, transcription factor.
Dürnberger et al. Genome Biology 2013 14:R81 doi:10.1186/gb-2013-14-7-r81