Micro-computed tomography (μCT) analysis of distal femur showed similar trabecular bone parameters in 14-week-old C57BL/6J and C57BL/6N mice. (A) Males and (B) females. (C) Cortical bone parameters from midshaft femur of 14-week-old male mice were also unchanged between the two strains. (D) Measurement of serum osteocalcin and urinary deoxypyridinoline (bone formation and bone resorption markers, respectively), indicates that bone turnover was identical between 14-week-old C57BL/6J and C57BL/6N. Abbreviations: BV/TV, bone volume/tissue volume; TbN, trabecular number; TbSp, Trabecular spacing; Conn-Dens, Connectivity density; SMI, structural model index (0 for parallel plates, 3 for cylindrical rods); DA, degree of anisotropy; CtPo, cortical porosity; CtTh, cortical thickness; DPD, deoxypyridinoline; creat, creatinin.
Simon et al. Genome Biology 2013 14:R82 doi:10.1186/gb-2013-14-7-r82