Resolution:
## Figure 3.
Maximum likelihood estimation and search. (A) Log likelihoods over different values of (the es-timate of α) and _{AA,AB }(the estimate of G_{AA,BB}, the probability that the control genotype is AA and the disease genotype is AB).
The surface graph shows that likelihoods are maximized around the true α values (10%
(left), 50% (middle), 90% (right)). (B) Search paths using the feasible direction method on contour maps. The method efficiently
finds the optimum points (green circles) in only a few search steps. Searches from
different starting points (blue circles) finally converge.
Kim |