Figure 3.

5hmC was enriched at H3K27me3 loci in embryonic stem cells (ESCs) but not in differentiated cells. (A) Heatmaps of 5hmC and H3K27me3 of genomic regions around the TSS (± 5 kb) in ESCs, mouse embryonic fibroblasts (MEFs), brain, and liver, rank-ordered by mRNA expression level of each cell type. (B) Profile distribution of 5hmC and H3K27me3 at the TSS (± 5kb) in H3K27me3-positive genes.