Comparative analysis of the domain organization of the C-type lectin-domain-containing protein. The dataset includes representative sequences of each protein group similar to the putative C-type lectin toxin. The different groups were identified after phylogenetic analysis of BLASTp hits retrieved on Tox-Prot and Uniprot databases associated with an e-value below 1E-05. To identify domains similar to those of platypus sequence parts, an alignment of the putative toxin and similar hits was performed using BLASTp. Domains associated with an e-value less than 1E-05 are indicated by colored boxes. The only shared motif is the C-type lectin domain. A sequence logo of the multiple alignment of C-type-lectin domains is represented above. Compared are the rat Rattus norvegicus, the chimpanzee Pan troglodytes, the water snake Enhydris polylepsis, the toadfish Thalassophryne natterei and the pit viper Trimeresurus flavoviridis.
Terrat and Ducancel Genome Biology 2013 14:406 doi:10.1186/gb-2013-14-9-406