Table 3 |
|||||
| AgeCGs and nonageCGs affiliated with gene expression within tissues classified by CpG contexta | |||||
| AgeCGs/genesb | Non-ageCGs/genesc | P-valued | |||
| Expressed | Non-expressed | Expressed | Non-expressed | ||
| Blood | |||||
| All | 271 (46.2) | 315 (53.8) | 4610 (78.4) | 1270 (21.6) | <2.2 × 10-16 * |
| Island only | 121 (36.1) | 214 (63.9) | 2251 (89.0) | 277 (11.0) | <2.2 × 10-16 * |
| Shore only | 101 (72.7) | 38 (27.3) | 1610 (83.5) | 317 (16.5) | 1.5 × 10-3 * |
| Other only | 49 (43.8) | 63 (56.2) | 749 (52.6) | 676 (47.4) | 0.09 |
| Brain | |||||
| All | 591 (78.8) | 159 (21.2) | 4404 (89.3) | 528 (10.7) | 3.5 × 10-16 * |
| Island only | 328 (79.4) | 85 (20.6) | 2243 (97.0) | 70 (3.0) | <2.2 × 10-16 * |
| Shore only | 184 (85.6) | 31 (14.4) | 1564 (95.0) | 82 (5.0) | 1.2 × 10-7 * |
| Other only | 79 (64.8) | 43 (35.2) | 597 (61.4) | 376 (38.6) | 0.53 |
| Kidney | |||||
| All | 1209 (77.4) | 354 (22.6) | 4046 (89.9) | 456 (10.1) | <2.2 × 10-16 * |
| Island only | 402 (71.2) | 163 (28.8) | 2089 (97.5) | 54 (2.5) | <2.2 × 10-16 * |
| Shore only | 440 (85.8) | 73 (14.2) | 1362 (95.0) | 71 (5.0) | 1.1 × 10-11 * |
| Other onlye | 367 (75.7) | 118 (24.3) | 595 (64.3) | 331(35.7) | 1.6 × 10-5 * |
| Muscle | |||||
| Allf | 515 (77.2) | 152 (22.8) | 2784 (71.8) | 1095 (28.2) | 4.2 × 10-3 |
| Island only | 258 (78.4) | 71 (21.6) | 1262 (87.3) | 184 (12.7) | 5.2 × 10-5 * |
| Shore only | 142 (86.1) | 23 (13.9) | 1065 (82.0) | 233 (18.0) | 0.24 |
| Other only | 115 (66.5) | 58 (33.5) | 457 (40.3) | 678 (59.7) | 1.6 × 10-10 * |
aExpressed genes, FPKM > 0.25; non-expressed genes, FPKM < 0.05. Parentheses indicate percentage of total in each CpG context category.
b,cGenes in proximity to an ageCG or non-ageCG according to the smallest age-associated P-value for representative genes in each tissue.
dResulting P-values from Pearson’s Chi-squared tests between numbers of ageCGs and non-ageCGs within each classification.
eAgeCGs/genes found within CGOs from kidney showed a significantly greater number of expressed genes compared to non-ageCGs in kidney.
fMuscle was the only tissue that showed a greater number of total ageCGs/genes expressed compared to non-ageCGs/genes regardless of CpG contextthis same effect was observed within the CGO category.
*Significant P-values meet Bonferroni correction for multiple testing.
Day et al.
Day et al. Genome Biology 2013 14:R102 doi:10.1186/gb-2013-14-9-r102
