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Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

Oskar Marín-Béjar1, Francesco P Marchese1, Alejandro Athie1, Yolanda Sánchez1, Jovanna González1, Victor Segura1, Lulu Huang2, Isabel Moreno3, Alfons Navarro4, Mariano Monzó4, Jesús García-Foncillas5, John L Rinn6, Shuling Guo2 and Maite Huarte1*

Author Affiliations

1 Center for Applied Medical Research, University of Navarra, 55 Pio XII Avenue., 31008 Pamplona, Spain

2 Department of Antisense Drug Discovery, Isis Pharmaceuticals, 2855 Gazelle Court., Carlsbad, CA 92008, USA

3 Department of Medical Oncology, Hospital Municipal de Badalona, 9-13 Via Augusta Street, 08911 Badalona, Spain

4 Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, University of Barcelona Medical School, IDIBAPS, 143 Casanova Street, 080360 Barcelona, Spain

5 Department of Oncology, Translational Oncology Division, Health Research Institute Fundación Jiménez Díaz University Hospital, Autonomous University of Madrid, 2 Reyes Catolicos Avenue, 28040 Madrid, Spain

6 Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA

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Genome Biology 2013, 14:R104  doi:10.1186/gb-2013-14-9-r104

Published: 26 September 2013

Additional files

Additional file 1:

Supplemental materials and methods, and supplementary figures with figure legends and PINT sequences.

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Additional file 2:

Table S1. p53 response elements (p53REs). found in mouse and human PINT genomic loci.

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Additional file 3:

Table S2 Genes affected by Pint inhibition.

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Additional file 4:

Table S3 Predicted upstream regulators of genes affected by Pint knockdown.

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Additional file 5:

Table S4 Genes affected by p53 inhibition.

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Additional file 6:

Table S5 Genes commonly affected by Pint and p53 inhibition.

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Additional file 7:

Table S6 Genes regulated by Pint and bound by Suz12 [31].

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Additional file 8:

Table S7 Information on the human samples used in this study.

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