Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
1 Center for Applied Medical Research, University of Navarra, 55 Pio XII Avenue., 31008 Pamplona, Spain
2 Department of Antisense Drug Discovery, Isis Pharmaceuticals, 2855 Gazelle Court., Carlsbad, CA 92008, USA
3 Department of Medical Oncology, Hospital Municipal de Badalona, 9-13 Via Augusta Street, 08911 Badalona, Spain
4 Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, University of Barcelona Medical School, IDIBAPS, 143 Casanova Street, 080360 Barcelona, Spain
5 Department of Oncology, Translational Oncology Division, Health Research Institute Fundación Jiménez Díaz University Hospital, Autonomous University of Madrid, 2 Reyes Catolicos Avenue, 28040 Madrid, Spain
6 Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Genome Biology 2013, 14:R104 doi:10.1186/gb-2013-14-9-r104Published: 26 September 2013
Additional file 1:
Supplemental materials and methods, and supplementary figures with figure legends and PINT sequences.
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Additional file 2:
Table S1. p53 response elements (p53REs). found in mouse and human PINT genomic loci.
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Additional file 3:
Table S2 Genes affected by Pint inhibition.
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Additional file 4:
Table S3 Predicted upstream regulators of genes affected by Pint knockdown.
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Additional file 5:
Table S4 Genes affected by p53 inhibition.
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Additional file 6:
Table S5 Genes commonly affected by Pint and p53 inhibition.
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Additional file 7:
Table S6 Genes regulated by Pint and bound by Suz12 .
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Additional file 8:
Table S7 Information on the human samples used in this study.
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