Resolution:
## Figure 5.
MommeD mutants show abnormal embryonic development. Timed matings and intercrosses of MommeD mutants. (a)Wiz^{MommeD30} mice; data show the number of mice observed (and in brackets the percentage) at 10.5
days post-coitum (dpc), 12.5 dpc, 14.5 dpc and at weaning. Representative embryos
are shown. (b)Rif1^{MommeD18} mice; data show the number of mice observed (and in brackets the percentage) at 10.5
to 12.5 dpc, 14.5 dpc and at weaning. na, not applicable. (c)Rlf mutants; data show the number of mice observed (and in brackets the percentage).
Embryonic weights were measured from intercrosses of Rlf^{MommeD34} and Rlf^{MommeD28} mice. Homozygous embryos from both had a significant increase in weight variation
at 17.5 dpc or 16.5 dpc, respectively. Weights for each litter were normalized to
the average weight of wild-type embryos in that litter. Each data point represents
an individual. Homozygotes were smaller than wild-type littermates at one week after
birth. ns, not significant. (d)Setdb1^{MommeD13} and Setdb1^{MommeD17} mice; data show the number of mice observed (and in brackets the percentage). (e)Smarcc1^{MommeD19} and Smarcc1^{MommeD19} mated to wild-type mice revealed incomplete penetrance of heterozygous lethality
after birth. Data show the number of mice (and in brackets the percentage). Weights
of 17.5 dpc Smarcc1^{MommeD19} embryos and pups were, on average, less than that of wild-type littermates (T-test,
P < 0.0001) and showed greater variation (F-test, P < 0.05). Weights in each litter were normalized to the average weight of wild-type
embryos in that litter. Each data point represents an individual. (f)Smarca4^{MommeD39} heterozygotes showed reduced viability. Data show the number of mice and in brackets
the percentage. Heterozygotes were smaller than their wild-type littermates. Smarc4^{MommeD39/+} weighed less (T-test, P < 0.0001) and weights were more variable (F-test, P<0.0001) than wild types. Weights
in each litter were normalized to the average weight of wild-type embryos in that
litter. Each data point represents an individual.
Daxinger |