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Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Jessica Nordlund1, Christofer L Bäcklin2, Per Wahlberg1, Stephan Busche3, Eva C Berglund1, Maija-Leena Eloranta4, Trond Flaegstad145, Erik Forestier146, Britt-Marie Frost147, Arja Harila-Saari1489, Mats Heyman149, Ólafur G Jónsson1014, Rolf Larsson2, Josefine Palle1147, Lars Rönnblom4, Kjeld Schmiegelow1114, Daniel Sinnett12, Stefan Söderhäll147, Tomi Pastinen133, Mats G Gustafsson2, Gudmar Lönnerholm147 and Ann-Christine Syvänen1*

Author Affiliations

1 Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden

2 Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala 75185, Sweden

3 Department of Human Genetics, McGill University, Montréal, Québec H3A0G1, Canada

4 Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala 75185, Sweden

5 Department of Pediatrics, Tromsø University and University Hospital, Tromsø N-9038, Norway

6 Department of Medical Biosciences, University of Umeå, Umeå 90185, Sweden

7 Department of Women’s and Children’s Health, Pediatric Oncology, Uppsala University, Uppsala 75185, Sweden

8 Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu 90029, Finland

9 Childhood Cancer Research Unit, Karolinska Institutet, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm 17176, Sweden

10 Pediatric Hematology-Oncology, Children’s Hospital, Barnaspitali Hringsins, Landspitali University Hospital, Reykjavik 101, Iceland

11 ediatrics and Adolescent Medicine, Rigshospitalet, and the Medical Faculty, Institute of Clinical Medicine, University of Copenhagen, Copenhagen 2100, Denmark

12 Division of Hematology-Oncology, CHU Sainte-Justine Research Center, Department of Pediatrics, University of Montreal, Montréal, Québec, Canada

13 Department of Human Genetics, McGill University and Genome Quebec Innovation Center, Montréal, Québec H3T1C5, Canada

14 For the Nordic Society of Pediatric Hematology and Oncology (NOPHO

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Genome Biology 2013, 14:r105  doi:10.1186/gb-2013-14-9-r105

Published: 24 September 2013

Additional files

Additional file 1: Table S1:

(Tab delimited .txt) Probe-level annotations for the 485,577 probes on the 450k array, including a column denoting the 435,941 CpG sites analyzed in the current study. Columns representing the differentially methylated CpG (DMC) signatures are included.

Format: ZIP Size: 20MB Download file

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Additional file 2: Tables S2 to S18:

Supplemental Tables S2 to S18.

Format: XLSX Size: 4.9MB Download file

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Additional file 3: Figures S1 to S16:

Supplemental Figures S1 to S16.

Format: DOCX Size: 1.9MB Download file

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Additional file 4:

Supplemental materials and methods.

Format: DOCX Size: 37KB Download file

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