To be or not to be a piRNA: genomic origin and processing of piRNAs
1 California Institute of Technology, Division of Biology, 147-75, 1200E California Blvd, Pasadena, CA 91125, USA
2 Université Pierre et Marie Curie, Ecole Doctorale Complexité du Vivant, 75005, Paris, France
Genome Biology 2014, 15:204 doi:10.1186/gb4154Published: 27 January 2014
Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.