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Review

To be or not to be a piRNA: genomic origin and processing of piRNAs

Adrien Le Thomas12, Katalin Fejes Tóth1 and Alexei A Aravin1*

Author Affiliations

1 California Institute of Technology, Division of Biology, 147-75, 1200E California Blvd, Pasadena, CA 91125, USA

2 Université Pierre et Marie Curie, Ecole Doctorale Complexité du Vivant, 75005, Paris, France

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Genome Biology 2014, 15:204  doi:10.1186/gb4154

Published: 27 January 2014

Abstract

Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.