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Using high-density DNA methylation arrays to profile copy number alterations

Andrew Feber1*, Paul Guilhamon1, Matthias Lechner1, Tim Fenton1, Gareth A Wilson1, Christina Thirlwell1, Tiffany J Morris1, Adrienne M Flanagan12, Andrew E Teschendorff1, John D Kelly13 and Stephan Beck1

Author Affiliations

1 UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK

2 Royal National Orthopaedic Hospital, Stanmore, Brockly Hill, Middlesex HA7 4LP, UK

3 Division of Surgery and Interventional Science, UCL Medical School, University College London, London WC1E 6BT, UK

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Genome Biology 2014, 15:R30  doi:10.1186/gb-2014-15-2-r30

Published: 3 February 2014

Additional files

Additional file 1: Figures S1 to S5:

Figure S1. Distribution of beta values for promoter associated and non-associated CpGs. (A) Boxplot of beta values for CpGs in non-CpG island associated promoters and CpG island associated promoters for regions of genomic amplification. (B) Regions of genomic deletion, (C) Regions of genomic loss, (D) CNA neutral regions and (E) Regions of single copy gain.

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