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Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein-coding RNAs

Jörg Hackermüller123*, Kristin Reiche123, Christian Otto45, Nadine Hösler56, Conny Blumert67, Katja Brocke-Heidrich6, Levin Böhlig8, Anne Nitsche4, Katharina Kasack356, Peter Ahnert59, Wolfgang Krupp10, Kurt Engeland8, Peter F Stadler11121334 and Friedemann Horn67

Author Affiliations

1 Young Investigators Group Bioinformatics and Transcriptomics, Department Proteomics, Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany

2 Department for Computer Science, University of Leipzig, Leipzig, Germany

3 RNomics Group, Department of Diagnostics, Fraunhofer Institute for Cell Therapy and Immunology – IZI, Leipzig, Germany

4 Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany

5 LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany

6 Institute of Clinical Immunology, University of Leipzig, Leipzig, Germany

7 Department of Diagnostics, Fraunhofer Institute for Cell Therapy and Immunology – IZI, Leipzig, Germany

8 Molecular Oncology, Medical School, University of Leipzig, Leipzig, Germany

9 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

10 Clinic of Neurosurgery, University of Leipzig, Leipzig, Germany

11 Max-Planck Institute for Mathematics in the Sciences, Leipzig, Germany

12 Santa Fe Institute, Santa Fe, NM, USA

13 Department of Theoretical Chemistry, University of Vienna, Vienna, Austria

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Genome Biology 2014, 15:R48  doi:10.1186/gb-2014-15-3-r48

Published: 4 March 2014

Additional files

Additional file 1:

Supplemental material.

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Additional file 2:

Online supplemental material containing BED formatted files of differentially expressed regions and macroRNAs, as well as CSV tables listing all proximal ncRNA-mRNA pairs regulated in astrocytoma.

Format: ZIP Size: 12.9MB Download file

Open Data