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Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

Matthew N Davies1*, Lutz Krause2, Jordana T Bell1, Fei Gao3, Kirsten J Ward1, Honglong Wu3, Hanlin Lu3, Yuan Liu3, Pei-Chein Tsai1, David A Collier4, Therese Murphy5, Emma Dempster5, Jonathan Mill45, UK Brain Expression Consortium, Alexis Battle7, Sara Mostafavi7, Xiaowei Zhu7, Anjali Henders2, Enda Byrne26, Naomi R Wray26, Nicholas G Martin2, Tim D Spector1 and Jun Wang3

Author Affiliations

1 Department of Twin Research & Genetic Epidemiology, King’s College London, St Thomas’ Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK

2 Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia

3 BGI-Shenzhen, Shenzhen 518083, China

4 SGDP Centre, Institute of Psychiatry, King’s College London, London SE5 8AF, UK

5 Medical School, University of Exeter, Exeter EX1 2LU, UK

6 Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia

7 Stanford University, Stanford, CA 94305, USA

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Genome Biology 2014, 15:R56  doi:10.1186/gb-2014-15-4-r56

Published: 2 April 2014

Additional files

Additional file 1: Table S1:

linear mixed model on TwinsUK dataset RPM values showing values for age, depression, smoking, alcohol and BMI. The nearest gene feature to a DMR is shown; DMRs occurring within a coding region are shown in bold. Table S2. linear mixed model on RPM factoring values for age, depression, smoking, alcohol, BMI and anti-depressant medication. The nearest gene feature to a DMR is shown, DMRs occurring within a coding region are shown in bold. Table S3. linear mixed model on RPM factoring values for age, depression, smoking, alcohol and BMI removing twin pairs taking anti-depressant medication. The nearest gene feature to a DMR is shown; DMRs occurring within a coding region are shown in bold. Table S4. linear mixed model on Queensland dataset RPM values showing values for age, depression, smoking, alcohol and BMI. The nearest gene feature to a DMR is shown; DMRs occurring within a coding region are shown in bold. Figure S1. averaged expression values of the ZBTB20 gene across 10 brain regions. Figure S2. ZBTBT20 exon 33 and exon 45 case-control comparison for the RNA-seq expression data.

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