Figure 3.

DNA methylation in specific gene regions. Distribution of DNA methylation in specific gene regions is shown. Each gene region is further divided into bins that correspond to beta values with 0.1 intervals. The area of each bin corresponds to total number of CpGs. The overall distribution and the mean of beta value of the CpGs in each gene region are shown as a box plot. The most unmethylated regions are associated with promoter sequences (TSS1500, TSS200, and 5′-UTR) and the first exon, while the most methylated regions are in the gene body and 3′-UTR. The numbers on the x-axis correspond to total number of CpGs in each gene region; also the x-axis shows different gene regions, and the y-axis shows the beta values.

Lokk et al. Genome Biology 2014 15:r54   doi:10.1186/gb-2014-15-4-r54
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