CGI methylation in different genomic regions. Distribution of DNA methylation in specific gene regions is shown. Each gene region is further divided into bins that correspond to beta values with 0.1 intervals. The area of each bin corresponds to total number of CpGs. The overall distribution and the mean of beta value of the CpGs in each gene region are shown as a box plot. (A) The distribution of DNA methylation in CGI and non-CGI regions shows that the CGI itself is largely unmethylated and that the shores and shelves are methylated. (B, C) The distribution of CGI and non-CGI DNA methylation in intergenic (B) and intragenic (C) regions. (A-C) The numbers on the x-axis correspond to total number of CpGs in each gene region; also the x-axis shows different genomic regions, and the y-axis shows the beta values.
Lokk et al. Genome Biology 2014 15:r54 doi:10.1186/gb-2014-15-4-r54